Endocrine Abstracts

Lipodystrophy syndromes are a rare and heterogeneous disease characterized by loss of subcutaneous adipose tissue, deposition of fat in ectopic areas, and consequently metabolic impairment, and its recognition is based on physical examination and clinical history. Because of the complexity of the disease, pregnancy represents a dainty and challenging event, still understudied. Here we report a case of a 28 year-old Caucasian female followed for type 2 diabetes and hypertriglyc...

Here we report a case of an adult patient (44y/o) followed for type-2 diabetes since he was 15 years, hypercholesterolemia treated with PCSK9 inhibitors and hypertension. At physical examination he presented: progeroid features, prominent forehead, hypertelorism, short palpebral fissures, broad nasal bridge, baldness, and hypotricosis. He was also affected by hearing loss with a jarring voice and lost teeth in early age. He showed developmental delay and ID, mild atrial septal...

Background: Data on the relationship between type 2 diabetes (T2D) and cancer consistently suggests the involvement of metabolic mechanisms such as inflammation, obesity, and glucose alteration. These mechanisms, including the activation of factors like IGF-1 or m-TOR, may influence the development of cancer.Aim: Our study had two main objectives. Firstly, we aimed to investigate the relationship between specific identifiable factors associated with T2D ...